Abstract:
Chromene (2-14 Chromene) contains benzopyran ring structures exhibit a large number of
biological activities such as antihypertensive, gastro protective agent, antitumor activity,
anticoagulant, antibacterial, vasodilator, anthelminthic activities. Pyrazole derivatives show a
vast range of biological activity such as anti-inflammatory, antimicrobial, selective enzyme
inhibitors such as oxidoreductase and alchohal dehydrogenase, CNS regulants. hypoglycemic
activity, antihypertensive activity. Chromene itself biologically active molecule if combine
chromene with pyrazole expect to increase biological activity. An efficient method developed for
synthesis of nitrochromane based pyrazole derivatives. Intermediates nitro styrenes (la-lOa)
synthesized by reaction of different aldehydes with nitromethane in presence of sodium
hydroxide at 0 0C to room temperature obtained upto 95% yield. Nitrochromcne (lb-lOb) are
synthesized from nitro styrene and salicyldehyde using DABCO as a catalyst under solvent free
condition in excellent yield (80-92%). Nitrochromane based 1,3 diones (Ic-lOc) synthesized via
Michael addition of 1,3 dione on nitrchromcne in presence of potassium carbonate at room
temperature in good yield (70%-80%), which condensed with hydrazine hydrate to form
pyrazole derivative (id-lOd) in excellent yield (84-96%).
