Abstract:
The thesis entitled “Design and synthesis of N, O-containing heterocycles” is reported
in five chapters.
The present work is aimed to design and synthesis of N and O containing
heterocyclic compound via different novel methodology involving C―C, C―O, C―N
bonds formation using different reactions like knoevenagel condensation, Aza Michael
addition with sequential dehydrogenation, oxiadative C―C bond cleavage and Ullman
type reaction. The synthesized compounds were characterization through different
analytical techniques such as 1H NMR, 13C NMR, HRMS and x-ray diffraction and their
biological evaluations were reported as calcium calmodulin dependent protein kinase
applications. Heterocyclic compounds are widely distributed in nature. All living things are made up
of genetic material and this genetic material are made up of DNA, Which contains
heterocycles moities like purine and pyrimidine as base. Beside these naturally occurring
alkaloids such as morphine, vinblastine, papaverine, phenazine; anibiotics such as
penicillin, cephalosporin moieties contains heterocyclic rings. Vitamin B complex
contains corrin and benzimidazole heterocyclic rings. There are many of natural product
having heterocyclic rings such as ascorbic acid, chlorophyll, hemoglobin, ATP, soft
drinks, dyes, amino acid. The colour of flowers due to anthocyanin which is the large
class of flavonoid family. Consequently the design of structurally diverse heterocyclic
compound is one of the driving forces for the development of organic chemistry. The
ability to create new heterocyclic compounds in an involuntary and efficient manner is
fundamental in many fields; for instance, in the industry heterocyclic compounds are used
in making cosmetics, textiles, plastics, lubricants and paints. Moreover they are most
extensively used in pharmaceuticals, because 90% of the medicines like analgesic,
antitumor, anticancer, antihypertensive drugs are made up of heterocyclic compounds.
Therefore, the precise synthesis of heterocyclic compounds is one of the main aims for
an organic chemist.
