Abstract:
Microfluidics is the branch of science which deals with the manipulation of fluids in the
sub-millimeter scale. With the evolution of technology, digital microfluidic (DMF) biochips
have become a vital part of biochemical research. It is a very small chip that performs thousands
of operations at the same time. It has a great impact on biomedical and biochemical
science. With the evolution in the fabrication technology, efficient microfluidic biochip
technologies have been proposed. The chip deals with performing operations on very small
volume fluids (like microlitre, nanolitre, picolitre, femtolitre). It performs droplet based
operations like sample preparation, mixing, routing, etc. Micro-electrode-dot-array digital
microfluidic (MEDA-DMF) biochips have advance features over traditional DMF biochips.
In this dissertation, we talk about one-pass synthesis approach for MEDA-DMF biochip.
We propose a routing algorithm for MEDA-DMF biochip which is based on the concepts of
computational geometry. We also propose well-defined library, architecture and bioassay
files which can be used as input for synthesis of biochip. We also decided to develop a tool
for MEDA-DMF biochip
