Abstract:
Since the discovery of the optical isomerism of tartaric acid, by Louis
Pasteur in 1848 the significance of stereoisomerism in relation to biological activity
has been well recognized. The physiological environment in living organism is
inherently chiral and therefore, the absorption, transport, action, degradation and
elimination of the molecules are different for different enantiomers. Thus the
development of chromatographic methods, especially those involving liquid
chromatography, for enantioseparation has been an intensive area of research. As in
the investigation of differences in biological effects, such as pharmacological and
toxicological properties, the chiral separation is equally important in chiral synthesis
also to know the enantiomeric composition of synthesized chiral compound.
Considering the importance of chiral analysis and role of chromatography in
enantioseparation following plan was devised for present study: ................................
