Abstract:
This thesis focusses on the investigating a suitable route to enable uptake of large
sized (30 nm and 60 nm) gold nanoparticles by pH responsive polymersornes of
diameters ranging from 110-140 nm. Addition of these gold nanoparticles(AuNP)
during self-as. seiiibly process of polymersomes. was Ibund to have poor encapsulation
efficiency after investigations by DLS, tiV-vis and Cryo-TEM. Moreover, a
significant size reduction was observed in case of encapsulated samples. Specific
interactions like inter-chain digitation. threading interactions and host-guest
complexal ion were employed to improve AuNP uptake by polvmersoines. However.
formation of PEG-AuNP hybrid due to interchain digitation by PEG was unsuccessful.
But, investigations with f3-Cyclodextrin modilied AuNP showed a possibility 11w their
/ uptake by threading complexation with PEG chains of polymersome5. Lastly.
successful uptake of large sized AuNPs by polymersomcs was acheived by host-guest
coinplexation betweeii 3-Cyclodextrin iinmobilised on AuNP and Adamantanc
moieties on the polymersonie.
