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Title: | DYNAMIC MODELLING OF FIXED BED BIOREACTORS |
Authors: | Dhiman, Amit Kumar |
Keywords: | CHEMICAL ENGINEERING;FIXED BED BIOREACTORS;POLYMER MATRIX ADSORBED;REACTOR SIMULATION |
Issue Date: | 2002 |
Abstract: | This study deals with the dynamic modelling of fixed-bed bioreactors. A mathematical model, which includes external film mass transfer, internal pore diffusion, axial dispersion and enzymatic reaction, is used to predict the performance of a fixed-bed bioreactor for the Sucrose-Invertase reaction. An Invertase (grade VII) enzyme immobilized by covalently binding it to polymer matrix adsorbed in the pores of Alumina is used. For the dynamic modelling of fixed-bed bioreactors, it is necessary to establish the model that best represents the reactor behaviour. In most cases, mathematical models that accurately describe industrial reactors cannot be solved analytically. With the aid of a computer, a variety of numerical methods can be used to solve the model. Mathematical models that describe various transport phenomena in a fixed-bed reactor were solved using a suitable numerical technique. Phenomena studied include heterogeneous effects, diffusion, axial dispersion and enzymatic reaction. Criteria were taken from literature to estimate the importance of these phenomena a-priori. These criteria were compared with the results of the computer simulations. In most cases, the criteria accurately predict which phenomena are important to a particular reactor simulation. Finally the model has been combined and a simulation package developed which calculates the concentration profiles for the reactor model chosen. |
URI: | http://hdl.handle.net/123456789/6751 |
Other Identifiers: | M.Tech |
Research Supervisor/ Guide: | Kumar, Surendra |
metadata.dc.type: | M.Tech Dessertation |
Appears in Collections: | MASTERS' THESES (Chemical Engg) |
Files in This Item:
File | Description | Size | Format | |
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CHD G10717.pdf | 2.7 MB | Adobe PDF | View/Open |
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