Regioselective N-Alkylation of Carbazole under Mild Condition

Abstract

Carbazole containing compounds have its separate predominance in the field of drug development. Now a days it is also utilizing for the development of fluorescent probes and solar cells. Generally different type of drugs which contains carbazole moiety have substitution on nitrogen atom but at the same time it is also known that synthesizing N-substituted carbazoles is a tedious task because these compounds are quite unstable and easily decomposed.Here in this work, N-alkylated carbazole product with 2-benzylidenemalononitrile by using inorganic base under mild reaction conditions. This is first N-alkylated carbazole product obtained by the reaction between 2-benzylidenemalononitrile and carbazole. The N-alkylated product obtained up to 55% yield.