Synthesis and characterization of antioxidants loaded BSA nanoparticles

Abstract

The primary goal of thus study to study the characterization of BSA ( protein) conjugated Sulforaphane and Quercetin prepared by desolvation method. The major function of the BSA is providing stability in the formation of nanoparticle and make it more biocompatible, bioavailable and biodegradable. COPD(Chronic obstructive pulmonary disease) is the chronic inflammation of lungs that obstruct the path of airways to exchange from lungs to bloodstream due to damaged surface of alveoli. The disease is characterized by losing the natural elasticity of the lung tissue which make the lung in more contracting position. pulmonary inflammation, protease-antiprotease imbalance, oxidant- antioxidant imbalance , both adaptive and innate immunity plays a key role in pathology of drug . The whole dissertation work showed the comparison between drug delivery (Sulforaphane and Quercetin) and their different combination as antioxidant therapy to treat COPD effectively. In addition to Sulforaphane, Quercetin drug might work synergistically with that and help to relax the lung muscle more promiently. The most important feature of this therapy is the person has to face very less side effects and it might help in tissue repair of the lungs. The antioxidant activity of Sulforaphane and Quercetin both help to eliminate the free radicals generated during COPD.