SYNTHESIS AND CHARACTERIZATION OF METAL OXIDE NANOCOMPOSITE FOR BIOMEDICAL APPLICATION

Abstract

Polysaccharides such as glucosaminoglycans (GAGs) and their analogues are promising candidates for making biocompatible metal oxide nanoparticles for biomedical applications. The development of a new polysaccharide coated on the surface of magnetic metal, metal oxide nanoparticles is a tremendous challenge since magnetic metal nanoparticles have potential applications in both detection and treatment of various diseases. Dextran sulfate polysaccharide is a well studied analogue of GAGs. It's a biologically active biomolecule That has unique properties like biodegradable, biocompatible, anti-inflammatory, and anticoagulant. Dextran sulfate is a strongly polyanionic compound, that forms a stable combination with their opposite ions during polyelectrolyte complexation and has been employed in polysaccharide-based nanoparticles with great success. In the present study, noble Dextran sulfate coated TiO2 nanocomposite was synthesized by the already reported sol-gel method with certain changes made throughout the reaction. The prepared DS-TiO2 nanocomposite was freeze-dried to obtain the powder form. The synthesized DS-TiO2 powder with TiO2 nanoparticle powder were given for the characterization by various analytical techniques including XRD, TGA, FTIR, SEM, and TEM for analysis. All the characterization data of DS-TiO2 and bare TiO2 were compared side by side. As a result, the DS-TiO2 nanocomposite could be a promising contender for biomedical applications including MRI contrast agents and a well-defined carrier for anticancer drug delivery. Furthermore, theranostic use of DS-TiO2 nanocomposite may be viable if multiple medical diagnostic and therapeutic techniques are combined in the future. Because TiO2 NPs are antibacterial and have a high contrast effect, they can be employed for CT scans and MRIs, as previously reported.