POLYMER BASED NANO COMPOSITES FOR DRUG DELIVERY

Abstract

In the present study, Graphene Quantum Dots were successfully synthesized via hydrothermal method of preparation GQDs. Further, for the synthesis of anticancer drug loaded and GQD embedded microspheres, the anticancer drug was mixed with synthesized GQD sand then they are incorporated into poly-lactic acid (PLA) and using poly-vinyl-acetate (PVA) as surfactant via solvent evaporation technique and single emulsification method. The successful synthesis of anticancer drug loaded microspheres were confirmed by several characterization techniques including Field-Emission Scanning Electron Microscopy (FE-SEM) which the morphology of microspheres and its shape and size, Fourier Transform Infrared Spectroscopy (FTIR) analysis, Differential light scattering (DLS) determined that the size of drug loaded microspheres are optimum and X-ray diffraction (XRD) showed about the composition and crystallinity of drug. TGA (Thermo gravimetric analysis) showed about the effect of temperature on drug loaded microspheres. The release characteristics were determined by UV-Vis spectrophotometric analysis. Furthermore the in-vitro cell based cytotoxicity assay showed negligible cytotoxicity of NCI-H522 cell line (Human, Lung, Non-small cell lung cancer).