DESIGN AND SYNTHESIS OF N, O-CONTAINING HETEROCYCLES

Abstract

The thesis entitled “Design and synthesis of N, O-containing heterocycles” is reported in five chapters. The present work is aimed to design and synthesis of N and O containing heterocyclic compound via different novel methodology involving C―C, C―O, C―N bonds formation using different reactions like knoevenagel condensation, Aza Michael addition with sequential dehydrogenation, oxiadative C―C bond cleavage and Ullman type reaction. The synthesized compounds were characterization through different analytical techniques such as 1H NMR, 13C NMR, HRMS and x-ray diffraction and their biological evaluations were reported as calcium calmodulin dependent protein kinase applications. Heterocyclic compounds are widely distributed in nature. All living things are made up of genetic material and this genetic material are made up of DNA, Which contains heterocycles moities like purine and pyrimidine as base. Beside these naturally occurring alkaloids such as morphine, vinblastine, papaverine, phenazine; anibiotics such as penicillin, cephalosporin moieties contains heterocyclic rings. Vitamin B complex contains corrin and benzimidazole heterocyclic rings. There are many of natural product having heterocyclic rings such as ascorbic acid, chlorophyll, hemoglobin, ATP, soft drinks, dyes, amino acid. The colour of flowers due to anthocyanin which is the large class of flavonoid family. Consequently the design of structurally diverse heterocyclic compound is one of the driving forces for the development of organic chemistry. The ability to create new heterocyclic compounds in an involuntary and efficient manner is fundamental in many fields; for instance, in the industry heterocyclic compounds are used in making cosmetics, textiles, plastics, lubricants and paints. Moreover they are most extensively used in pharmaceuticals, because 90% of the medicines like analgesic, antitumor, anticancer, antihypertensive drugs are made up of heterocyclic compounds. Therefore, the precise synthesis of heterocyclic compounds is one of the main aims for an organic chemist.