DESING AUTOMATION FOR MICRO ELECTRODE DOT ARRAY BASED DIGITAL MICROFLUIDIC BIOCHIPS

Abstract

Microfluidics is the branch of science which deals with the manipulation of fluids in the sub-millimeter scale. With the evolution of technology, digital microfluidic (DMF) biochips have become a vital part of biochemical research. It is a very small chip that performs thousands of operations at the same time. It has a great impact on biomedical and biochemical science. With the evolution in the fabrication technology, efficient microfluidic biochip technologies have been proposed. The chip deals with performing operations on very small volume fluids (like microlitre, nanolitre, picolitre, femtolitre). It performs droplet based operations like sample preparation, mixing, routing, etc. Micro-electrode-dot-array digital microfluidic (MEDA-DMF) biochips have advance features over traditional DMF biochips. In this dissertation, we talk about one-pass synthesis approach for MEDA-DMF biochip. We propose a routing algorithm for MEDA-DMF biochip which is based on the concepts of computational geometry. We also propose well-defined library, architecture and bioassay files which can be used as input for synthesis of biochip. We also decided to develop a tool for MEDA-DMF biochip