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|Title:||SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME HETEROCYCLIC COMPOUNDS|
|Abstract:||Inflammatory diseases and cancer are serious health problems faced by human beings. A number of anti inflammatory and a few anticancer drugs are available in the market. Long term use of anti-inflammatory drugs can cause gastric ulcer, kidney damage and heart failure etc. There is urgent need to develop new safer anti-inflammatory drugs. In order to have sufficient number of anticancer drugs there is need to search newpotent anticancer compounds which can be developed as anticancer drugs. Efforts have been made by us in this direction, which is described in this thesis. For the sake of clarity, the work embodied in this thesis is divided into five chapters. First Chapter : General introduction: In part la of this this chapter recent work reported in literature on the use of microwave technology in organic synthesis is summarized. In part lb recent recent work reported in literature on the synthesis, anti-inflammatory and anticancer activities evaluation of thiazole, thiazoline, sulfonamide, amidine, cyclic imides, Schiff bases, benzimidazole and isoquinolinone derivatives is described. All the new compounds synthesized and reported in the following chapters were charaterized by IR, *H NMR, Mass (GC-MS, FAB-MS) spectroscopy and elemantal analysis. Second Chapter: In this chapter synthesis of 3,4-diaryl-2-imino-4-thiazolines (Ia-m), methanesulfonamide (Ha-j) and amidine (IHa-j) derivatives of 3,4-diaryl-2-imino-4-thiazolines (Ia-m) by following reaction scheme 2.1, 2.2 & 2.3 is discussed.Thiazolines la-fare known in literature whereas Igm are unknown............................|
|Appears in Collections:||DOCTORAL THESES (chemistry)|
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