SYNTHESIS, BIOLOGICAL EVALUATION AND ANALYTICAL APPLICATIONS OF N AND S CONTAINING HETEROCYCLIC LIGANDS

Abstract

Heterocyclic compounds have established place as drugs and useful analytical reagents. A large number of antiinflammatory, antiamoebic and anthelmintic drugs are available in the market but most of these drugs have serious side effects. This necessitates a need for the development of effective and safer antiinflammatory, antiamoebic and anthelmintic drugs. Development of new reagents which are selective and sensitive for the determination of various metals is another field of current interest. Number of laboratories all over the world are engaged in the above mentioned fields of research. This is quite evident from the large number of research papers/patents published every year in the areas described. Work included in the thesis deals with the synthesis of some N and S containing heterocyclic compounds. Efforts have also been made by us to explore the biological and analytical utility of the synthesized compounds, which are illustrated in this thesis. For the sake of clarity, the work embodied in the thesis has been divided into five chapters. Chapter I It deals with a general introduction; this chapter consists of two parts 1.1 and 1.2. 1.1. This part deals with the recent literature reported on the synthesis and biological evaluation of pyrimidine derivatives. 1.2. It describes recent work reported in literature on the determination and liquid-liquid extraction of Pd(II), Hg(II) and Fe(III). Chapter - II The details about the materials and equipments used tor the present study arc given in this chapter. Partition studies were carried out using UV-Vis Spectrophotometer, radiotracers and Inductively Coupled Plasma-Atomic Emission Spectrometry (ICP-AES). The analysis of medicinal plants, dental amalgam, Pdcalalysts, Waste water effluents and synthetic samples was carried out employing ICP ..............