http://localhost:8081/jspui/handle/123456789/15071 2025-07-18T20:37:41Z 2025-07-18T20:37:41Z Tammareddy, Harshini http://localhost:8081/jspui/handle/123456789/15087 2021-09-01T04:52:55Z 2014-05-01T00:00:00Z

Title: SURFACE ADHESIVES FOR REMOVAL OF KIDNEY STONE FRAGMENTS Authors: Tammareddy, Harshini Abstract: Current technologies implemented for removing kidney stones are complex and doesnot achieve 100% removal of kidney stones. The objective of this project is to prepare formulations of bio adhesives for removing kidney stone fragments that were left in the patient's body after Percutaneous Nephrolithotomy(PCNL) and ureteroscopy that pose significant morbidity to the 10 patient with urinary stones with upto 50 % requiring intervention within 5 years. Two kinds of nanoparticles were chosen for this study i.e., citrate coated gold nanoparticles and PVA coated iron oxide nanoparticles .Their surface properties were modified by coating them with various concentrations of Polydopamine(P-DOPA). Dopamine undergoes self-polymerization under mild basic conditions forming P-DOPA onto various organic and inorganic materials. Nanoparticles were immersed into dopamine solution at mild basic conditions in Tris buffer which leads to uniform coating of P-DOPA onto nanoparticles. These prepared samples were analysed using Dynamic Light Scattering and UV Spectroscopy. Polymerization reaction of P-DOPAonto nanoparticles was controlled by varying the ph of the buffer. On reducing the ph of solution P-DOPA coated nanoparticles were found to be iW aggregating which might be proven useful for improved iron loading efficiencies onto kidney stone fragments. Stability studies of P-DOPA coated nanoparticles for one week has been conducted. Adhesion of P-DOPA with kidney stone has been established by preparing Human Kidney stone pellet. Kidney stones, collected from Tan Tock Seng Hospital,Singapore, were crushed with pestle motar and pellet was prepared using Hydraulic press of ETIR .P-DOPA was coated onto these pellets and P-DOPA adhesion with kidney stone has been proved. In conclusion P-DOPA has been proved to be an ideal polymer for extracting kidney stone fragments.

2014-05-01T00:00:00Z Singhvi, Yash http://localhost:8081/jspui/handle/123456789/15086 2021-09-01T04:49:15Z 2014-06-01T00:00:00Z

Title: MOLECULAR SIMULATIONS OF INDUSTRIALLY RELEVANT POLYVINYL ACETATE (PVA) BASED COATINGS Authors: Singhvi, Yash Abstract: Polyvinyl acetate (PVA) based coatings find extensive applications in various coating and paint industries globally. Grafting and copolymeriZatiofl of PVA with oleophobic moieties/monomers has resulted in potential coating formulations that possess enhanced stain-resistance. Molecular simulations have been long used to understand the behavior of specialty polymers and their blends. In this work, we employ molecular dynamics simulation to understand the effect of copolymeriZati0fl of fluoro based moieties- Vinylfluoride(VF) and VinylidenediflU0ride('') with PVA on the oleophobic and related performance properties of formulated coatings at various compositions. Material Studio software available from AccelrysTM has been employed for running Molecular Dynamics (MD) simulations to estimate useful properties with widely used force field- It COMPASS. Proper comparisons between the results have been made and finally recommendation is proposed about the advantage of adding selective fluorine based monomers,ofl various performance parameters of coating,on PVA backbone.

2014-06-01T00:00:00Z Shankhar, S. Gowri http://localhost:8081/jspui/handle/123456789/15085 2021-09-01T04:46:35Z 2014-06-01T00:00:00Z

Title: STENGTH ANALYSIS OF 3D PRINTED POLYMER MATERIALS Authors: Shankhar, S. Gowri Abstract: 3D Printing or Rapid Prototyping has been next big thing in manufacturing industry so far. But materials that are 3D printed are observed to have less strength. Systematic study on the strength of printed materials is still needed. In this work, the. strength of a 3D printed material is analysed with different orientations and base area systematically. Using the software Minitab a design of experiment has been done to study how the strength varies when other parameters like base area, angle are changed both individually and simultaneously. Finally an equation has been formed relating Strength, Base area and angle

2014-06-01T00:00:00Z Ravikiran, Muley Abhijit http://localhost:8081/jspui/handle/123456789/15084 2021-09-01T04:24:39Z 2014-06-01T00:00:00Z

Title: STUDY OF INHIBITOR BINDING TO BIOLOGICAL MACROMOLECULES USING ATOMISTIC MODELING AND SIMULATION Authors: Ravikiran, Muley Abhijit Abstract: Mammalian target of rapamycin (mTOR) is a large (-250 kDa) naturally occurring biological molecule that plays a critical role in controlling cell growth. Using adenosine triphosphate (ATP) as a substrate, mTOR tags target proteins with phosphate groups (phosphorylation) to turn on their activity. Deregulation of mTOR has been linked to diseases such as cancer and diabetes, therefore in recent times a lot of attention has been paid to developing mTOR inhibitors having high efficacy and specificity. While ATPcompetitive inhibitors have shown promising results in experimental studies, a high resolution picture of ligand binding to mTOR that can guide design of better drugs has been missing. Recently, a low resolution (3.5 A) crystal structure of the mTOR protein complex was captured 1, which might provide a starting point to study ligand binding in mTOR. However, major challenges remain in providing a structural basis for the binding and action of various ligands to mTOR. These include the lack of suitable techniques for quantitatively studying structural changes in such a large protein complex (- 1500 amino acids), and the lack of information on protein conformation changes and flexibility in the presence and absence of ligands. Further, the recently solved low resolution crystal structure has many unresolved (missing atoms) protein segments. In this study, we complete the missing structural information in the low resolution crystal structure and set up a high resolution fully solvated atomistic model of the mTOR protein. Further, as a step towards incorporating thermally induced conformational changes, we have created a molecular dynamics model for the solvated mTOR complex in the absence and presence of its natural ATP substrate. Finally, we report a novel analysis technique which we have developed to quantify the conformational and dynamic changes taking place in mTOR during ATP binding. We have successfully validated this technique by testing on amyloid beta for which deformation path is well-known.

2014-06-01T00:00:00Z